Neither wins outright: Mistral: Mixtral 8x22B Instruct is the pick when cost matters at scale, OpenAI: GPT-4o when you need to fit long inputs in one request.
Monthly cost at list price for five common workloads. Token counts per unit are stated so you can scale them to your own traffic. A workload that does not fit a model's context window is marked rather than priced.
Workload (per month)
Mistral: Mixtral 8x22B Instruct
OpenAI: GPT-4o
Difference
Customer-support chatbot
50,000 conversations — each a 6-turn conversation (1,500 in / 400 out tokens)
$270
$388
Mistral: Mixtral 8x22B Instruct saves $118
RAG search over documents
20,000 questions — each a question answered from ~8 retrieved passages (6,000 in / 500 out tokens)
$300
$400
Mistral: Mixtral 8x22B Instruct saves $100
Coding / tool-using agent
2,000 tasks — each a multi-step task with tool calls and file context (60,000 in / 6,000 out tokens)
Doesn't fit context
$420
—
Batch summarisation
10,000 documents — each a 6,000-word report summarised to a page (8,000 in / 600 out tokens)
$196
$260
Mistral: Mixtral 8x22B Instruct saves $64.00
Long-document analysis
500 documents — each a 150-page contract or codebase read in one pass (100,000 in / 2,000 out tokens)
Doesn't fit context
$135
—
Capabilities side by side
Capability
Mistral: Mixtral 8x22B Instruct
OpenAI: GPT-4o
What it lets you do
Tool / function calling
✓ Yes
✓ Yes
call your APIs and run agent loops
Structured output (JSON schema)
✓ Yes
✓ Yes
return JSON that validates against your schema
Reasoning / thinking mode
—
—
spend extra tokens thinking before answering hard problems
Image input
—
✓ Yes
read screenshots, charts and scanned pages
Audio input
—
—
take speech or audio directly
File / PDF input
✓ Yes
✓ Yes
accept documents without your own parsing step
Image output
—
—
generate images, not just text
Built-in web search
—
✓ Yes
answer from live web results
Seed (reproducible sampling)
✓ Yes
✓ Yes
repeat a generation for tests and evals
Log-probabilities
—
✓ Yes
read token confidence for classification and scoring
From each model's published parameters and input/output types. “—” means not advertised, not proven absent.
Price history
Mistral: Mixtral 8x22B Instruct: price unchanged since we started tracking it on 2026-03-10.
OpenAI: GPT-4o: price unchanged since we started tracking it on 2026-03-10.
Which should you choose?
Choose Mistral: Mixtral 8x22B Instruct if…
cost matters at scale — it is 31% cheaper on a typical 3:1 input/output mix ($270 vs $388 a month for 50,000 support chats)
you generate long outputs in one go — up to 52K tokens (about 39,300 words) per response
Choose OpenAI: GPT-4o if…
you need to fit long inputs in one request — 128K tokens is roughly 192 pages, against 98
you need image input — to read screenshots, charts and scanned pages; Mistral: Mixtral 8x22B Instruct does not advertise it
you need built-in web search — to answer from live web results; Mistral: Mixtral 8x22B Instruct does not advertise it
you need log-probabilities — to read token confidence for classification and scoring; Mistral: Mixtral 8x22B Instruct does not advertise it
Frequently asked questions
Is Mistral: Mixtral 8x22B Instruct better than OpenAI: GPT-4o?
Neither wins outright: Mistral: Mixtral 8x22B Instruct is the pick when cost matters at scale, OpenAI: GPT-4o when you need to fit long inputs in one request. In short: Mistral: Mixtral 8x22B Instruct when cost matters at scale, you generate long outputs in one go; OpenAI: GPT-4o when you need to fit long inputs in one request, you need image input, you need built-in web search, you need log-probabilities.
Which is cheaper, Mistral: Mixtral 8x22B Instruct or OpenAI: GPT-4o?
Mistral: Mixtral 8x22B Instruct is cheaper: $3.00 vs $4.38 per 1M tokens at a typical 3:1 input/output mix, 31% less. For 50,000 support conversations a month that is $270 against $388.
How much do Mistral: Mixtral 8x22B Instruct and OpenAI: GPT-4o cost per million tokens?
Mistral: Mixtral 8x22B Instruct costs $2.00 per 1M input tokens and $6.00 per 1M output tokens; OpenAI: GPT-4o costs $2.50 input and $10.00 output. Output tokens are billed separately, so long answers shift the gap.
Which has the bigger context window, Mistral: Mixtral 8x22B Instruct or OpenAI: GPT-4o?
OpenAI: GPT-4o: 128K tokens, about 192 pages, against 66K (about 98 pages) for Mistral: Mixtral 8x22B Instruct.
Do Mistral: Mixtral 8x22B Instruct and OpenAI: GPT-4o support function calling and JSON output?
Mistral's official instruct fine-tuned version of [Mixtral 8x22B](/models/mistralai/mixtral-8x22b). It uses 39B active parameters out of 141B, offering unparalleled cost efficiency for its size. Its strengths include: - strong math, coding,...
GPT-4o ("o" for "omni") is OpenAI's latest AI model, supporting both text and image inputs with text outputs. It maintains the intelligence level of [GPT-4 Turbo](/models/openai/gpt-4-turbo) while being twice as...