AionLabs: Aion 3.5 vs Mistral: Mixtral 8x22B Instruct
Neither wins outright: AionLabs: Aion 3.5 is the pick when you need to fit long inputs in one request, Mistral: Mixtral 8x22B Instruct when cost matters at scale.
Monthly cost at list price for five common workloads. Token counts per unit are stated so you can scale them to your own traffic. A workload that does not fit a model's context window is marked rather than priced.
Workload (per month)
AionLabs: Aion 3.5
Mistral: Mixtral 8x22B Instruct
Difference
Customer-support chatbot
50,000 conversations — each a 6-turn conversation (1,500 in / 400 out tokens)
$345
$270
Mistral: Mixtral 8x22B Instruct saves $75.00
RAG search over documents
20,000 questions — each a question answered from ~8 retrieved passages (6,000 in / 500 out tokens)
$420
$300
Mistral: Mixtral 8x22B Instruct saves $120
Coding / tool-using agent
2,000 tasks — each a multi-step task with tool calls and file context (60,000 in / 6,000 out tokens)
$432
Doesn't fit context
—
Batch summarisation
10,000 documents — each a 6,000-word report summarised to a page (8,000 in / 600 out tokens)
$276
$196
Mistral: Mixtral 8x22B Instruct saves $80.00
Long-document analysis
500 documents — each a 150-page contract or codebase read in one pass (100,000 in / 2,000 out tokens)
$156
Doesn't fit context
—
Capabilities side by side
Capability
AionLabs: Aion 3.5
Mistral: Mixtral 8x22B Instruct
What it lets you do
Tool / function calling
✓ Yes
✓ Yes
call your APIs and run agent loops
Structured output (JSON schema)
✓ Yes
✓ Yes
return JSON that validates against your schema
Reasoning / thinking mode
✓ Yes
—
spend extra tokens thinking before answering hard problems
Image input
—
—
read screenshots, charts and scanned pages
Audio input
—
—
take speech or audio directly
File / PDF input
—
✓ Yes
accept documents without your own parsing step
Image output
—
—
generate images, not just text
Built-in web search
—
—
answer from live web results
Seed (reproducible sampling)
—
✓ Yes
repeat a generation for tests and evals
Log-probabilities
—
—
read token confidence for classification and scoring
From each model's published parameters and input/output types. “—” means not advertised, not proven absent.
Price history
AionLabs: Aion 3.5: price unchanged since we started tracking it on 2026-09-24.
Mistral: Mixtral 8x22B Instruct: price unchanged since we started tracking it on 2026-03-10.
Which should you choose?
Choose AionLabs: Aion 3.5 if…
you need to fit long inputs in one request — 262K tokens is roughly 393 pages, against 98
you need reasoning / thinking mode — to spend extra tokens thinking before answering hard problems; Mistral: Mixtral 8x22B Instruct does not advertise it
you want the newer model — released 2026-09-23, 30 months after the other
Choose Mistral: Mixtral 8x22B Instruct if…
cost matters at scale — it is 20% cheaper on a typical 3:1 input/output mix ($270 vs $345 a month for 50,000 support chats)
you need file / PDF input — to accept documents without your own parsing step; AionLabs: Aion 3.5 does not advertise it
you need seed (reproducible sampling) — to repeat a generation for tests and evals; AionLabs: Aion 3.5 does not advertise it
you generate long outputs in one go — up to 52K tokens (about 39,300 words) per response
Frequently asked questions
Is AionLabs: Aion 3.5 better than Mistral: Mixtral 8x22B Instruct?
Neither wins outright: AionLabs: Aion 3.5 is the pick when you need to fit long inputs in one request, Mistral: Mixtral 8x22B Instruct when cost matters at scale. In short: AionLabs: Aion 3.5 when you need to fit long inputs in one request, you need reasoning / thinking mode, you want the newer model; Mistral: Mixtral 8x22B Instruct when cost matters at scale, you need file / PDF input, you need seed (reproducible sampling), you generate long outputs in one go.
Which is cheaper, AionLabs: Aion 3.5 or Mistral: Mixtral 8x22B Instruct?
Mistral: Mixtral 8x22B Instruct is cheaper: $3.00 vs $3.75 per 1M tokens at a typical 3:1 input/output mix, 20% less. For 50,000 support conversations a month that is $270 against $345.
How much do AionLabs: Aion 3.5 and Mistral: Mixtral 8x22B Instruct cost per million tokens?
AionLabs: Aion 3.5 costs $3.00 per 1M input tokens and $6.00 per 1M output tokens; Mistral: Mixtral 8x22B Instruct costs $2.00 input and $6.00 output. Output tokens are billed separately, so long answers shift the gap.
Which has the bigger context window, AionLabs: Aion 3.5 or Mistral: Mixtral 8x22B Instruct?
AionLabs: Aion 3.5: 262K tokens, about 393 pages, against 66K (about 98 pages) for Mistral: Mixtral 8x22B Instruct.
Do AionLabs: Aion 3.5 and Mistral: Mixtral 8x22B Instruct support function calling and JSON output?
Aion 3.5 is a multi-model roleplaying and storytelling system from AionLabs, built on the GLM family of models. It uses a collaborative generation process in which multiple specialized models each...
Mistral's official instruct fine-tuned version of [Mixtral 8x22B](/models/mistralai/mixtral-8x22b). It uses 39B active parameters out of 141B, offering unparalleled cost efficiency for its size. Its strengths include: - strong math, coding,...